T-cell receptor sequences for active immunotherapy
AssigneePolybiocept AB
InventorsMarkus MAEURER, Ernest DODOO
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Abstract
The present invention provides a protein, in particular a TCR comprising a Vβ amino acid sequence with a sequence identity of at 90%, to a sequence selected from SEQ ID NO: 1 to 27, a T-cell comprising the TCR a method of selecting a T-cell product for use in active immunotherapy based on the identification of an Vβ amino acid sequence with a sequence identity of at 90%, to a sequence selected from SEQ ID NO: 1 to 27 in a T-cell product.
Claims17
A protein comprising a Vbeta sequence with an amino acid sequence with a sequence identity of at least 90% to a sequence selected from SEQ ID NO:
- 1 to 26.
A method of selecting a T-cell product for use in active immunotherapy in a patient, wherein the method comprises the following steps:
- a) providing one or more T-cell products;
- b) identifying the presence of a TCR comprising a sequence with an identity of at least 95% to the sequence selected from SEQ ID NO:
- 1 to 27 in the one or more T-cell products;
- and
- c) selecting the T-cell product comprising a TCR identified in step b) for use in therapy.
Dependencies are inferred from the claim text.