Compositions for preventing or treating lupus

A pharmaceutical composition for preventing or treating lupus, comprising a compound represented by a following formula I, an optical isomer thereof or a pharmaceutically acceptable salt thereof as an effective component:

• wherein
• A is
• Xa and Xb are each independently CH or N,
• L1 and L2 are each independently hydrogen, halogen, —CF3 or —C1-3 straight or branched chain alkyl,
• Q is C(═O), S(═O)2, S(═O) or C(═NH),
• Y is selected from a following group:
• M is C, N, O, S or S(═O) 2, wherein, at this time, in case M is C, 1 and m are 1;
• in case M is N, 1 is 1 and m is 0;
• and in case M is O, S or S(═O)2, 1 and m are 0,
• Ra1 and Ra2 are each independently hydrogen;
• hydroxy;
• —C1-4 straight or branched chain alkyl, which is unsubstituted or substituted with at least one halogen;
• —C1-4 straight or branched chain alcohol;
• benzhydryl;
• —C1-4 straight or branched chain alkyl, which is substituted with a saturated or unsaturated 5- to 7-membered heterocyclized compound comprising 1 to 3 heteroatoms of N, O or S as a ring member, wherein, at this time, the heterocyclized compound may be unsubstituted or at least one hydrogen may be optionally substituted with OH, OCH3, CH3, CH2CH3 or halogen;
• a saturated or unsaturated 5- to 7-membered heterocyclized compound comprising 1 to 3 heteroatoms of N, O or S as a ring member, wherein, at this time, the heterocyclized compound may be unsubstituted or at least one hydrogen may be optionally substituted with OH, OCH3, CH3, CH2CH3 or halogen;
• phenyl, wherein it is unsubstituted or at least one hydrogen is substituted with halogen, C1-4 alkoxy, C1-2 alkyl or hydroxy;
• benzyl, wherein it is unsubstituted or at least one hydrogen is substituted with halogen, C1-4 alkoxy, C1-2 alkyl or hydroxy;
• —S(═O) 2CH3;
• halogen;
• —C1-6 straight or branched chain alkoxy;
• —C2-6 alkoxyalkyl;
• —C(═O)Rx, wherein R , is straight or branched chain C1-3 alkyl or C3-10 cycloalkyl;
• where Rc
• and Rd are each independently hydrogen, C1-3 straight or branched chain alkyl;
• and
• n is an integer of 0, 1 or 2,
• Rb is hydrogen;
• hydroxy;
• —C1-6 straight or branched chain alkyl,
• wherein it is unsubstituted or at least one hydrogen is substituted with halogen;
• —C(═O)CH 3;
• —C1.4 straight or branched chain hydroxyalkyl;
• —C1-6 straight or branched chain alkoxy;
• —C2.6 straight or branched chain alkoxyalkyl;
• —CF3;
• halogen;
• or
• Re and Rf are each independently hydrogen or —C1-3 straight or branched chain alkyl,
• Z is selected from a following group:
• Pa and Pb are each independently
• hydrogen;
• hydroxy;
• —C1-4 straight or branched chain alkyl, wherein it is unsubstituted or at least one hydrogen is substituted with halogen;
• halogen;
• -CF 3;
• -OCF 3;
• —CN;
• —C1-6 straight or branched chain alkoxy;
• —C2-6 straight or branched chain alkyl alkoxy;
• -—CH2F;
• or —C1-3 alcohol,
• where
• is phenyl, pyridine, pyrimidine, thiazole, indole, indazole, piperazine, quinoline, furan, tetrahydropyridine, piperidine or a ring selected from a following group:
• x, y and z are each independently an integer of 0 or 1,
• Rg1, Rg2 and R g3 are each independently hydrogen;
• hydroxy;
• —C1-3 alkyl;
• —CF3;
• —C1-6 straight or branched chain alkoxy;
• —C 2-6 straight or branched chain alkyl alkoxy;
• —C(═O)CH3;
• —C1-4 straight or branched chain hydroxyalkyl;
• —N(CH3)2;
• halogen;
• phenyl;
• —S((═O)2)CH3;
• or selected from a following group: