Compositions and methods to protect mammalian tissue against cold and other metabolic stresses
AssigneeThe United States of America, AS Represented By the Secrectary, Department of Health and Human Serv
InventorsJingxing Ou, Wei Li, Kiyoharu Josh Miyagishima
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Abstract
A composition for preserving viability of cells, tissues, or organs at a low temperature is provided. The composition includes a mitochondrial uncoupling agent, at least one protease inhibitor, and a reducing agent. Methods to protect cells, tissues, or organs from exposure to cold and other metabolic stress are also provided.
Claims21
A composition for preserving the viability of cells, tissues, or organs during exposure to a low temperature environment, the composition comprising:
- a mitochondrial uncoupling agent;
- at least one protease inhibitor;
- and
- a reducing agent.
A method for treating mammalian cells, tissues, or organs to withstand exposure to a low temperature environment during therapy, treatment, or a medical procedure, the method comprising the steps of:
- providing mammalian cells, tissues, or organs to be exposed to a low temperature environment;
- providing a composition comprising a mitochondrial uncoupling agent, at least one protease inhibitor, and a reducing agent;
- contacting said mammalian cells, tissues, or organs with said composition to enable said mammalian cells, tissues, or organs withstand exposure to a low temperature environment.
Dependencies are inferred from the claim text.