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US 2020/0368208 A1Published application
Protein Translation Inhibitors and Uses Thereof
AssigneeUniversity of Baltimore, Maryland
InventorsFrance Carrier, Alexander D. MacKerell, David J. Weber, Wenbo Yu
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Abstract
Provided herein are protein translation inhibitors and pharmaceutical compositions thereof that bind to an RNA Recognition motif in heterogeneous ribonucleoprotein A18 to inhibit binding to mRNA transcripts thereby inhibiting protein synthesis. Also provided is a method for treating a cancer by administering a pharmaceutically acceptable amounts of at least one of the protein translation inhibitors.
Claims20
A protein translation inhibitor, comprising:
- a compound with a chemical structure that binds to an RNA Recognition motif in a heterogeneous ribonucleoprotein A18.
A method for treating a cancer in a subject in need thereof comprising the step of:
- administering to the subject a therapeutically effective amount of a protein translation administering to the subject a therapeutically effective amount of a protein translation inhibitor, thereby inhibiting translation of a protein associated with the cancer.
Dependencies are inferred from the claim text.