Methods for increasing fertility

A method of treating or preventing infertility in a female subject suffering from infertility or a decline in fertility, or at risk of suffering from infertility or a decline in fertility the method comprising administering to the subject an effective amount of an agent which elevates SIRT2 activity or SIRT2 expression in the subject.

The method of claim 1, wherein the subject is a subject who has been, is being, or will be, treated with chemotherapy, or has an underlying predisposition to infertility.

A method of increasing BubR1 activity in an oocyte, and/or increasing the fertilisation potential of an oocyte, comprising introducing into the oocyte an effective amount of an agent which elevates SIRT2 activity or SIRT2 expression in the oocyte.

A method of fertilizing an oocyte in vitro, comprising introducing into the oocyte a donor sperm and an effective amount of an agent which elevates SIRT2 activity or SIRT2 expression in the oocyte.

A method of increasing the probability that a zygote produced by fertilization of an oocyte in vitro will progress to a full term pregnancy following implantation, comprising introducing into the oocyte prior to, during, or after, fertilisation of the oocyte, an effective amount of an agent which elevates SIRT2 activity or SIRT2 expression in the oocyte.

A method of improving or enhancing the ability of an oocyte to form a blastocyst during IVF, comprising introducing into the oocyte an effective amount of an agent which elevates SIRT2 activity or SIRT2 expression in a subject.