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US 2020/0368171 A1Published application
Particles
AssigneeMicroVention, Inc.
InventorsMakoto Harumoto, Gregory M. Cruise, Michael Kebede
Life of this patent
Estimating the term…
Abstract
Described are particles configured for intravascular delivery of pharmaceutical agents to a diseased site.
Claims20
An embolic particle comprising:
- a reaction product of a prepolymer solution including:
- at least one monomer selected from acrylamide, methacrylamide, dimethyl acrylamide, glyercol monomethacrylate, hydroxypropyl acrylate, hydroxyethyl methacrylate, hydroxyethyl acrylate, hydroxybutyl acrylate, methyl methacrylate, tert-butyl acrylate, n-butyl acrylate, n-butyl methacrylate, n-hexyl acrylate, methoxyethyl acrylate, iso-decyl acrylate, 2-ethylhexyl acrylate, stearyl acrylate, N-(tert-octyl) acrylamide, N-octyl methacrylate, or a combinations thereof,
- at least one crosslinker selected from N,N′-methylenebisacrylamide, ethylene glycol dimethacrylate,
- or a combination thereof, and
- at least one pharmaceutical agent,
- wherein the at least one pharmaceutical agent is chemically entrapped in the embolic particle.
3 more elements
A method of treating a vessel comprising:
- delivering polymer particles to the vessel to treat the vessel, wherein the polymer particles are a reaction product of a prepolymer solution including at least one monomer, at least one crosslinker, and at least one pharmaceutical agent,
- wherein the at least one pharmaceutical agent is chemically entrapped in the polymer particles.
A method of making polymer particles that elute at least one pharmaceutical agent, the method comprising:
- reacting a prepolymer solution including at least one monomer, at least one crosslinker, at least one initiator and at least one pharmaceutical agent in a solvent, and
- forming the polymer particles and encapsulating the at least one pharmaceutical agent.
Dependencies are inferred from the claim text.