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US 2020/0368169 A1Published application
Abuse-deterrent compositions
AssigneePatheon Softgels, Inc.
InventorsSaujanya Gosangari, Justin Hughey, Tatyana Dyakonov, George VAMVAKAS, Aqeel A. FATMI
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Abstract
Described herein are abuse deterrent controlled release oral pharmaceutical compositions comprising and methods for making the same. In particular, an abuse deterrent controlled release oral pharmaceutical composition comprising a soft capsule and an abuse deterrent controlled release matrix comprising an active pharmaceutical ingredient are described.
Claims16
An oral pharmaceutical composition comprising:
- a soft gelatin capsule shell encapsulating a tamper resistant, homogenous, viscous, yet flowable matrix consisting essentially of:
- (a) hydrophobic matrix phase comprising:
- one or more lipophilic vehicles consisting of about 25% to about 85% of the flowable matrix mass;
- and
- optionally one or more semisolid lipids consisting of 0% to about 10% of the flowable matrix;
- (b) a hydrophilic phase comprising:
- one or more hydrophilic polymers consisting of about 8% to about 50% of the flowable matrix mass;
- one or more hydrophilic vehicles consisting of about 2% to about 60% of the flowable matrix mass;
- and
- one or more organogelators consisting of about 0.5% to about 25% of the flowable matrix mass;
- and
- (c) one or more active pharmaceutical ingredients dissolved in the flowable matrix consisting of about 1% to about 35% of the flowable matrix mass.
9 more elements
Dependencies are inferred from the claim text.