Preservative removal from eye drops
AssigneeUniversity of Florida Research Foundation, Inc.
InventorsAnuj Chauhan, Phillip J. Dixon, Poorvajan Sekar
Life of this patent
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Abstract
A BAK removal device is constructed as a plug of microparticles of a hydrophilic polymeric gel that displays a hydraulic permeability greater than 0.01 Da. The polymer hydrophilic polymeric gel comprises poly(2-hydroxyethyl methacrylate) (pHEMA). The particles are 2 to 100 μm and the plug has a surface area of 30 mm2 to 2 mm2 and a length of 2 mm to 25 mm and wherein the microparticles of a hydrophilic polymeric gel has a pore radius of 3 to 60 μm.
Claims23
-24. (canceled)
A multi-dosing device for delivery of a solution, comprising:
- a bottle comprising:
- a reservoir comprising the solution disposed therein, wherein the solution comprises a hydrophobic therapeutic agent and a preservative;
- an outlet extension;
- and
- a preservative removing device disposed within the outlet extension and comprising a porous hydrophilic polymeric matrix, wherein upon delivery of the solution through the outlet extension the porous hydrophilic polymeric matrix is configured to remove at least 50% of a preservative and retain at least 50% of the hydrophobic therapeutic agent within the solution.
A method of administering a hydrophobic therapeutic agent using a multi-dosing device, comprising:
- providing a bottle comprising:
- an outlet extension;
- a reservoir comprising a solution disposed therein, wherein the solution comprises the hydrophobic therapeutic agent, a preservative;
- and
- a preservative removing device disposed within the outlet extension and comprising a porous hydrophilic polymeric matrix, wherein the preservative removing device when dry has dimensions smaller than the internal dimensions of the outlet extension, and wherein the preservative removing device when wet has dimensions larger than the internal dimensions of the outlet extension, and wherein upon delivery of the solution through the outlet extension the porous hydrophilic polymeric matrix is configured to remove at least 50% of a preservative and retain at least 50% of the hydrophobic therapeutic agent within the solution.
Dependencies are inferred from the claim text.