Method and system for consistent, repeatable, and safe cryospray treatment of airway tissue

A method for treating symptoms of COPD in an airway of a lung of a patient, comprising:

• advancing an energy transfer device to a target region in the airway;
• and
• transferring energy between the energy transfer device and the target region in an amount sufficient to remodel epithelial cells in the target region, such that one or more of the symptoms are improved.

A method for reducing mucus production in an airway of a lung of a patient, comprising:

• advancing an energy transfer device to a target region in the airway;
• and
• transferring energy between the energy transfer device and the target region in an amount sufficient to reduce epithelial cells in the target region, such that mucus production is reduced.

A method for treating a condition in an airway of a lung of a patient, comprising:

• advancing an energy transfer device to a target region in the airway;
• and
• transferring energy between the energy transfer device and the target region in an amount sufficient to alter epithelial cells in the target region, such that the condition is improved.