Systems and methods for biosensor cross-calibration

A system for delivery of insulin to a subject in need thereof, comprising:

• a first glucose biosensor;
• a second glucose biosensor;
• a mobile computing device, the mobile computing device including a processor, the processor storing instructions in non-transitory memory that, when executed, cause the processor to:
• receive a notification that the second glucose biosensor has been inserted into the subject while the first glucose biosensor is already inserted into the subject;
• initiate a cross calibration procedure within a determined amount of time subsequent to receiving the indication;
• obtain a first current from the first glucose sensor and a second current from the second biosensor;
• convert the first current to a first glucose value;
• predict a background current associated with the second sensor based at least in part on the first current, the second current and the first glucose value;
• subtract the background current from the second current to obtain a subtracted second current;
• create a conversion operation for converting the subtracted second current to a second glucose value, the conversion operation based at least in part on one or more of the first current and the first glucose value;
• convert the subtracted second current to the second glucose value based on the conversion operation;
• and
• provide a set of instructions pertaining to delivery of insulin to the subject based on the second glucose value.

An apparatus for calibrating a biosensor inserted into tissue of a subject, comprising:

• a mobile computing device including a processor, the processor storing instructions in non-transitory memory that, when executed, cause the processor to:
• while a first sensor is inserted into the tissue of the subject, detect insertion of a second sensor into the tissue;
• initiate a cross calibration procedure of the second sensor responsive to the detecting;
• obtain a first current from the first sensor and a second current from the second sensor, and convert the first current into a first analyte value;
• in response to an indication that predetermined conditions are met for modeling a first non-glucose driven background current associated with the second sensor, predict the first non-glucose driven background current for the second sensor over a first time duration;
• during the first time duration, subtract the first non-glucose driven background current from the second current to obtain a subtracted second current for the second sensor;
• and
• convert the subtracted second current to a second analyte value.

A non-transitory computer-readable storage medium with an executable program stored thereon for biosensor calibration, wherein the executable program instructs a microprocessor to perform the steps of:

• detecting that a second analyte sensor has been inserted into skin of a subject following insertion of a first analyte sensor into the skin of the subject, where insertion of the first analyte sensor occurs between one and thirty days prior to the second analyte sensor being inserted;
• initiating a cross calibration procedure based on the detecting;
• retrieving a first current from the first analyte sensor and a second current from the second analyte sensor, and converting the first current to a first analyte value within five seconds to sixty seconds of initiating the cross calibration procedure;
• determining that a current decay trend can be established for the second analyte sensor based on the second current within sixty seconds to one hour following initiation of the cross calibration procedure, and in response, predicting a background current extrapolated over a time duration based at least in part on the second current measured within sixty seconds to one hour following initiation of the cross calibration procedure;
• over the time duration, subtracting the background current profile from the second current to obtain a subtracted second current;
• and
• converting the subtracted second current to a second analyte value, thereby calibrating the second analyte sensor.