Image diagnostic system, and methods of operating thereof

A method for identifying one or more tissue types within an image patch according to a hierarchical histological taxonomy, the method comprises operating a processor to:

• access a set of training image patches stored in a supervised digital pathology database;
• develop a feature extractor to generate a training feature vector identifying one or more training tissue segments in each training image patch in the set of training image patches;
• develop a feature classifier to assign a tissue type to each training tissue segment identified in the training feature vector and to update a class confidence score for that tissue type, the tissue type being assigned according to the hierarchical histological taxonomy;
• apply the feature extractor to the image patch to identify one or more tissue segments within the image patch;
• and
• apply the feature classifier to assign a tissue type to the one or more tissue segments identified by the feature extractor for the image patch and to generate a confidence score for assigned tissue type within the image patch with reference to the class confidence score.

A non-transitory computer-readable medium comprising instructions executable on a processor for implementing a method for identifying one or more tissue types within an image patch according to a hierarchical histological taxonomy, the method comprising operating the processor to:

• access a set of training image patches stored in a supervised digital pathology database;
• develop a feature extractor to generate a training feature vector identifying one or more training tissue segments in each training image patch in the set of training image patches;
• develop a feature classifier to assign a tissue type to each training tissue segment identified in the training feature vector and to update a class confidence score for that tissue type. the tissue type being assigned according to the hierarchical histological taxonomy;
• apply the feature extractor to the image patch to identify one or more tissue segments within the image patch:
• and
• apply the feature classifier to assign a tissue type to the one or more tissue segments identified by the feature extractor for the image patch and to generate a confidence score for assigned tissue type within the image patch with reference to the class confidence score.