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US 2020/0348222 A1Published application
Particle Detection Methods and Systems for Practicing Same
AssigneeAbbott Laboratories
InventorsAmish P. Shah, Frederic M. Hulett, III
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Abstract
Aspects of the present disclosure include methods for detecting events in a flow cytometer. Also provided are methods of detecting cells in a flow cytometer. Other aspects of the present disclosure include methods for determining a level of contamination in a flow cell. Computer-readable media and systems, e.g., for practicing the methods summarized above, are also provided.
Claims9
1-50. (canceled)
A method of determining a level of contamination in a flow cell, comprising:
- flowing a sample comprising particles through a flow cell;
- collecting raw particle event data during the flowing;
- counting the number of particle events within the raw particle event data;
- filtering the raw particle event data with an inverse Gaussian filter coefficient to produce a filtered signal, wherein the inverse Gaussian filter coefficient is based on an expected power spectrum variance;
- determining the energy of the filtered signal;
- and
- subtracting a clean flow cell baseline energy from the determined energy of the filtered signal, to determine a level of contamination in the flow cell.
4 more elements
58-66. (canceled)
Dependencies are inferred from the claim text.