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US 2020/0347153 A1Published application
Methods for forming inclusion complexes with hydrophilic beta-cyclodextrin derivatives and compositions thereof
AssigneeTaka USA, Inc.
InventorsTakako Mohri McGowan, Sarah Catherine Hill
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Abstract
The described invention provides inclusion complexes of an active agent with a β-cyclodextrin, improved methods for their preparation, methods for characterization of the complexes, and formulation of the complexes as cosmetic compositions or pharmaceutical compositions.
Claims13
A method for improving incorporation of a guest compound in a cavity of a hydroxypropyl-β-cyclodextrin host comprising:
- (a) establishing a vacuum in the cavity of the hydroxypropyl-β-cyclodextrin (HPBCD);
- (b) adding the guest compound, wherein the guest compound is substantially free of a solvent;
- (c) incorporating the guest compound into the cavity;
- and
- (d) forming an active agent-hydroxypropyl-β-cyclodextrin inclusion complex.
2 more elements
Dependencies are inferred from the claim text.