Novel galactoside inhibitor of galectins

A D-galactopyranose compound of formula (1)

• wherein the pyranose ring is α-D-galactopyranose,
• R1 is selected from the group consisting of
• wherein the asterix * indicates the carbon atom of the heteroaromatic ring that is covalently attached to the triazole group of formula (1);
• wherein R2 is selected from the group consisting of OH and halogen;
• R3 is selected from the group consisting of hydrogen, C1-6 alkyl and halogen;
• R4 is selected from the group consisting of OH and halogen;
• R5 is selected from the group consisting of hydrogen, C1-6 alkyl and halogen;
• B1 is selected from a) an aryl, optionally substituted with a group selected from a halogen;
• CN;
• —COOH;
• —CONR29R30, wherein R29 and R30 are independently selected from H, C1-3 alkyl, cyclopropyl, and iso-propyl;
• C1-3 alkyl, optionally substituted with a F;
• cyclopropyl, optionally substituted with a F;
• isopropyl, optionally substituted with a F;
• OC1-3 alkyl, optionally substituted with a F;
• SC1-3 alkyl, optionally substituted with a F;
• O-cyclopropyl, optionally substituted with a F;
• O-isopropyl, optionally substituted with a F;
• NR31R32, wherein R31 and R32 are independently selected from H, C1-3 alkyl and isopropyl;
• OH;
• and R33—CONH—, wherein R33 is selected from C1-3 alkyl and cyclopropyl;
• b) a heterocycle, optionally substituted with a group selected from a halogen;
• CN;
• —COOH;
• —CONR35R36, wherein R35 and R36 are independently selected from H, C1-3 alkyl, cyclopropyl, and iso-propyl;
• C1-3 alkyl, optionally substituted with a F;
• cyclopropyl, optionally substituted with a F;
• isopropyl, optionally substituted with a F;
• OC1-3 alkyl, optionally substituted with a F;
• O-cyclopropyl, optionally substituted with a F;
• SC1-3 alkyl, optionally substituted with a F;
• O-isopropyl, optionally substituted with a F;
• NR37R38, wherein R37 and R38 are independently selected from H, C1-3 alkyl and isopropyl;
• OH;
• and R39—CONH— wherein R39 is selected from C1-3 alkyl and cyclopropyl;
• or
• a pharmaceutically acceptable salt or solvate thereof.