Compounds that participate in cooperative binding and uses thereof

A macrocyclic compound, or a pharmaceutically acceptable salt thereof, having the structure:

• wherein A is a target protein interacting moiety described by the structure of Formula XIII:
• wherein the dotted lines represent zero to three double bonds, provided that no two double bonds are adjacent to one another;
• R31 and R32 are independently hydrogen, hydroxyl, optionally substituted amino, halogen, thiol, optionally substituted amino acid, optionally substituted C1-C6 acyl, optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C1-C6 heteroalkyl, optionally substituted C2-C6 heteroalkenyl, optionally substituted C2-C6 heteroalkynyl, optionally substituted C3-C10 cycloalkyl, optionally substituted C4-C10 cycloalkenyl, optionally substituted C4-C10 cycloalkynyl, optionally substituted C5-C10 aryl, optionally substituted C5-C10 aryl C1-C6 alkyl, optionally substituted C2-C9 heteroaryl, optionally substituted C2-C9 heteroaryl C1-C6 alkyl, optionally substituted C2-C9 heterocyclyl, optionally substituted C2-C9 heterocyclyl C1-C6 alkyl, or R31 and R32 combine to form C═O;
• R33 is hydrogen or C═O, provided that no double bond is adjacent to a C═O;
• and
• B is a presenter protein binding moiety described by a structure selected from:
• and each of L1 and L2 is, independently, a linker.