Substituted pyrrolopyridines as jak inhibitors

A compound, or a derivative thereof, of Formula (II):

• wherein:
• R10 is selected from CN or a heteroaryl group and is optionally substituted at the one or more available nitrogen atoms with a group independently selected from H or C1-C5alkyl and at one or more available carbon atoms with substituents wherein each substituent is independently selected from H, halogen, CN, —C1-C4alkyl, —C0-C6alkylC3-C6cycloalkyl, —(C0-C6alkyl)C3-C6heterocycle, —OH, —SO2R90, —NHSO2R90, —OSO2R90, —C0-C6alkylSO2R90, C0-C6alkylCOR90, C0-C6alkylNR70C(O)NR70R80, C0-C6alkylOC(O)NR70R80, C0-C6alkylNR70SO2R90, —C0-C6alkylNR70COR90—OC1-C6alkyl, —OC0-C6alkylC3-C6cycloalkyl, —OC0-C6alkylC3-C6heterocycle, —OC0-C6alkylNR70C(O)NR70R80, —OC0-C6alkylOC(O)NR70R80, —OC0-C6alkylNR70SO2R90, —OC0-C6alkylNR70COR90, —NR70R80, —NR70C0-C6alkylC1-C6alkyl, —NR70C0-C6alkylC3-C6cycloalkyl, —NR70C0-C6alkylNR7C(O)NR70R80, —NR70C0-C6alkylOC(O)NR70R80, —NR70C0-C6alkylNR70SO2R90, —NR70C0-C6alkylNR70COR90, —NR70C0-C6alkylC3-C6heterocycle, aryl and heteroaryl wherein each alkyl, cycloalkyl, aryl, heterocyclyl, or heteroaryl group is optionally substituted with one or more groups selected from:
• halogen, —OH, —C0-C6alkylNR70R80, —C0-C6alkylOH, —SO2R9, —SOR90, —NHSO2R90, —C0-C6alkylNR70R40, CN, —C1-C5alkylalkoxy, C1-C5alkoxy or —O—C1-C5alkyl;
• R20 is selected from H, —C1-C4alkyl, —C3-C6cycloalkyl, or —C1-C2alkyl-C3-C6cycloalkyl, wherein the alkyl or cycloalkyl groups are optionally substituted with one or more groups selected from halogen, —OH, or —O—C1-C5alkyl;
• n is 0, 1 or 2;
• Ring B is substituted at one or more carbons with one, two, or three R30 substituents wherein each R30 substituent is independently selected from H, halogen, —C1-C4alkyl, —C3-C6cycloalkyl, —OH, or —O—C1-C5alkyl wherein each alkyl or cycloalkyl group is optionally substituted with one or more groups selected from:
• halogen, —OH, —C1-C5alkylalkoxy, or —O—C1-C5alkyl;
• Two R30 groups on the same or different carbon atoms of the ring B may be optionally joined to form a spirocyclic or bicyclic ring system with ring B;
• R40 is selected from —C(O)—R60, —CH2R60, —C(O)—C1-C5alkyl, or —C(O)—C3-C6cycloalkyl, wherein the alkyl or cycloalkyl groups may be optionally substituted with one or more groups selected from —OH, halogen, alkyne, or —CN;
• R50 is selected from —C1-C5alkyl, or —C3-C6cycloalkyl wherein the alkyl or cycloalkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —O—C1-C5alkyl;
• R60 is selected from —C1-C5alkyl, —C3-C6cycloalkyl, —C1-C5alkyl-C3-C6cycloalkyl, —NR70R80, —O-aryl, —O-heteroaryl, aryl, or heteroaryl wherein the alkyl, cycloalkyl, aryl or heteroaryl groups can be optionally substituted by one or more groups selected from halogen, —CN, alkyne, —OH, trifluoromethyl, —O—C1-C5alkyl, or —O—C3-C6cycloalkyl;
• R70 and R80 are independently selected from H, —C1-C5 alkyl, —C1-C5 alkoxy, or —C3-C5 cycloalkyl wherein the alkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —CN;
• R70 and R80 may be optionally joined to form a ring to form a heterocycle such as piperidine, pyrrolidine, or with another heteroatom to form a ring such as morpholine wherein the heterocyclic ring may be optionally substituted by one or more groups selected from halogen, —OH, NH2, NHMe, NMe2, or —CN;
• and
• R90 is selected from H, —C1-C5alkyl, —C3-C6cycloalkyl, and NR70R80 wherein the alkyl, heterocycle, or cycloalkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, NH2, NHMe, NMe2, or —CN.

A compound, or a derivative thereof, of Formula (III):

• wherein:
• R100 is selected from CN or a heteroaryl group and is substituted at the one or more available nitrogen atoms with a group independently selected from H or C1-C5alkyl and at one or more available carbon atoms with substituents wherein each substituent is independently selected from H, halogen, CN, —C1-C4alkyl, —C3-C6cycloalkyl, —OH, —O—C1-C5alkyl, —SO2R900, —NHSO2R900, —OSO2R900, —CH2SO2R900, (CH2)nCOR900, aryl and heteroaryl wherein each alkyl, cycloalkyl, aryl or heteroaryl group is optionally substituted with one or more groups selected from:
• halogen, —OH, NH2, NH—C1-C5alkyl, CN, —C1-C5alkylalkoxy, C1-C5alkoxy or —O—C1-C5alkyl;
• R200 is selected from H, —C1-C4alkyl, —C3-C6cycloalkyl, or —C1-C2alkyl-C3-C6cycloalkyl, wherein the alkyl or cycloalkyl groups are optionally substituted with one or more groups selected from halogen, —OH, or —O—C1-C5alkyl;
• n is 0, 1 or 2;
• Ring C is substituted at one or more carbons with one, two, or three R300 substituents wherein each R300 substituent is independently selected from H, halogen, —C1-C4alkyl, —C3-C6cycloalkyl, —OH, or —O—C1-C5alkyl wherein each alkyl or cycloalkyl group is optionally substituted with one or more groups selected from:
• halogen, —OH, —C1-C5alkylalkoxy, or —O—C1-C5alkyl;
• Two R300 groups on the same or different carbon atoms of the ring C may be optionally joined to form a spirocyclic or bicyclic ring system with ring C;
• R400 is selected from —C(O)—R600, —CH2R600, —C(O)—C1-C5alkyl, or —C(O)—C3-C6cycloalkyl, wherein the alkyl or cycloalkyl groups may be optionally substituted with one or more groups selected from —OH, halogen, alkyne, or —CN;
• R500 is selected from —C1-C5alkyl, or —C3-C6cycloalkyl wherein the alkyl or cycloalkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —O—C1-C5alkyl;
• R600 is selected from —C1-C5alkyl, —C3-C6cycloalkyl, —C1-C5alkyl-C3-C6cycloalkyl, —NR700R800, —O-aryl, —O-heteroaryl, aryl, or heteroaryl wherein the alkyl, cycloalkyl, aryl or heteroaryl groups can be optionally substituted by one or more groups selected from halogen, —CN, alkyne, —OH, trifluoromethyl, —O—C1-C5alkyl, or —O—C3-C6cycloalkyl;
• R700 and R800 are independently selected from H, —C1-C5 alkyl, —C1-C5 alkoxy, or —C3-C5 cycloalkyl wherein the alkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —CN;
• R700 and R800 may be optionally joined to form a ring to form a heterocycle such as piperidine, pyrrolidine, or with another heteroatom to form a ring such as morpholine;
• and
• R900 is selected from H, —C1-C5alkyl, —C3-C6cycloalkyl, and NR700R800 wherein the alkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —CN.

A compound, or a derivative thereof, of Formula (IV):

• wherein:
• R1000 is selected from CN or a heteroaryl group and is substituted at the one or more available nitrogen atoms with a group independently selected from H or C1-C5alkyl and at one or more available carbon atoms with substituents wherein each substituent is independently selected from H, halogen, CN, —C1-C4alkyl, —C3-C6cycloalkyl, —OH, —O—C1-C5alkyl, —SO2R9000, —NHSO2R9000, —OSO2R9000, —CH2SO2R9000, (CH2), COR9000, aryl and heteroaryl wherein each alkyl, cycloalkyl, aryl or heteroaryl group is optionally substituted with one or more groups selected from:
• halogen, —OH, NH2, NH—C1-C5alkyl, CN, —C1-C5alkylalkoxy, C1-C5alkoxy or —O—C1-C5alkyl;
• R2000 is selected from H, —C1-C4alkyl, —C3-C6cycloalkyl, or —C1-C2alkyl-C3-C6cycloalkyl, wherein the alkyl or cycloalkyl groups are optionally substituted with one or more groups selected from halogen, —OH, or —O—C1-C5alkyl;
• n is 0, 1 or 2;
• Ring D is substituted at one or more carbons with one, two, or three R3000 substituents wherein each R3000 substituent is independently selected from H, halogen, —C1-C4alkyl, —C3-C6cycloalkyl, —OH, or —O—C1-C5alkyl wherein each alkyl or cycloalkyl group is optionally substituted with one or more groups selected from:
• halogen, —OH, —C1-C5alkylalkoxy, or —O—C1-C5alkyl;
• Two R3000 groups on the same or different carbon atoms of the ring D may be optionally joined to form a spirocyclic or bicyclic ring system with ring D;
• R4000 is selected from —C(O)—R6000, —CH2R6000, —C(O)—C1-C5alkyl, or —C(O)—C3-C6cycloalkyl, wherein the alkyl or cycloalkyl groups may be optionally substituted with one or more groups selected from —OH, halogen, alkyne, or —CN;
• R5000 is selected from —C1-C5alkyl, or —C3-C6cycloalkyl wherein the alkyl or cycloalkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —O—C1-C5alkyl;
• R6000 is selected from —C1-C5alkyl, —C3-C6cycloalkyl, —C1-C5alkyl-C3-C6cycloalkyl, —NR7000R8000, —O-aryl, —O-heteroaryl, aryl, or heteroaryl wherein the alkyl, cycloalkyl, aryl or heteroaryl groups can be optionally substituted by one or more groups selected from halogen, —CN, alkyne, —OH, trifluoromethyl, —O—C1-C5alkyl, or —O—C3-C6cycloalkyl;
• R7000 and R8000 are independently selected from H, —C1-C5 alkyl, —C1-C5 alkoxy, or —C3-C5 cycloalkyl wherein the alkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —CN;
• R7000 and R8000 may be optionally joined to form a ring to form a heterocycle such as piperidine, pyrrolidine, or with another heteroatom to form a ring such as morpholine;
• and
• R9000 is selected from H, —C1-C5alkyl, —C3-C6cycloalkyl, and NR7000R8000 wherein the alkyl groups may be optionally substituted by one or more groups selected from halogen, —OH, or —CN.