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US 2020/0308258 A1Published application
Anti-herv-k envelope antibody and uses thereof
AssigneesGeneuro SA, The United States of America, as represented by the Secretary, Department of Health and
InventorsHervé PERRON, Julie MEDINA, Avindra NATH, Joseph Perry Steiner, Wenxue LI, Myoung-Hwa LEE
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Abstract
The present invention relates to a novel antibody against HERV-K envelope that targets a conserved region not affected by glycosylation or by native conformation, and its use in diagnostics and/or is therapy.
Claims7
1-9. (canceled)
An antibody that recognizes the HERV-K envelope protein, wherein said antibody comprises
- a light chain comprising a light chain variable region (VL) which comprises three complementary determining regions (CDR-L1, CDR-L2 and CDR-L3), and
- a heavy chain comprising a heavy chain variable region (VH) which comprises three complementary determining regions (CDR-H1, CDR-H2 and CDR-H3), wherein the CDR-L1 comprises the amino acid sequence of SEQ ID NO:1, the CDR-L2 comprises the amino acid sequence of SEQ ID NO:2, the CDR-L3 comprises the amino acid sequence of SEQ ID NO:3, the CDR-H1 comprises the amino acid sequence of SEQ ID NO:4, the CDR-H2 comprises the amino acid sequence of SEQ ID NO:5, the CDR-H3 comprises the amino acid sequence of SEQ ID NO:6.
Dependencies are inferred from the claim text.