Method for guidance of fluid therapy based on proadrenomedullin

Kit for therapy guidance, stratification and/or monitoring of a fluid therapy, comprising:

• detection reagents for determining the level of proADM or fragment(s) thereof in a sample from a subject,
• reference data, such as a reference level, corresponding to high, intermediate and/or low severity levels of proADM, wherein a low severity level of proADM or fragment(s) thereof is below 2.75 nmol/l±20%, wherein an intermediate severity level of proADM or fragment(s) thereof is from 2.75 nmol/l±20% to 10.9 nmol/l±20%, and wherein a high severity level of proADM or fragment(s) thereof is above 10.9 nmol/l±20%, wherein said reference data is stored on a computer readable medium and/or employed in the form of computer executable code configured for comparing the determined levels of proADM or fragment(s) thereof, and
• a pharmaceutical composition comprising a therapeutic fluid, preferably a colloid and optionally crystalloid solution.