Method for screening compounds that modulate the activity of the electron transport chain

A method for determining the effect of a compound on the activity of a component of the electron transport chain or any associated protein thereof, comprising:

• (i) putting into contact the compound with a sample comprising membranes containing a component of the electron transport chain or any associated protein thereof in the presence of a redox probe, and at least one electron donor compound of any of said component or protein, in conditions allowing the interaction between said compound and a component of the electron transport chain or any associated protein thereof present in said sample, between said electron donor compound and its corresponding component of the electron transport chain or any associated protein thereof and between said redox probe and a oxidative phosphorylation component of the electron transport chain;
• and
• (ii) quantifying the signal obtained due to the oxidation or reduction of said redox probe, wherein if the activity of a component of the electron transport chain or any associated protein thereof is increased, the compound is an inductor of one of the component of the electron transport chain or any associated protein thereof, and if the activity of a component of the electron transport chain or any associated protein thereof is reduced, the compound is an inhibitor of a component of the electron transport chain or any associated protein thereof.

A kit comprising a redox probe, at least one electron donor compound of a component of the electron transport chain or of a protein associated thereof.

(canceled)