Anti-coagulation factor xi antibodies
AssigneesMerck Sharp & Dohme Corp., Adimab, LLC
InventorsZhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Vaishnavi Ganti, Mohammad Tabrizifard, Bianka Prinz
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Abstract
Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Claims12
A method for producing an antibody or antigen binding fragment comprising (i) six complimentary determining regions (CDRs) of an anti-FXI antibody of the αFXI-18623p family, wherein the six CDRs comprise
- (a) CDR1, CDR2, and CDR3 of the heavy chain (HC) having the amino acid sequence shown in SEQ ID NO:43;
- and
- (b) CDR1, CDR2, and CDR3 of the light chain (LC) having the amino acid sequence shown in SEQ ID NO:31, the method comprising:
- providing a host cell comprising a nucleic acid molecule encoding the heavy chain and a nucleic acid molecule encoding the light chain;
- and cultivating the host cell under conditions and a time sufficient to produce the antibody or antigen binding fragment.
The method of claim2, wherein the antibody or antigen binding fragment comprises an HC variable domain having the amino acid sequence shown in SEQ ID NO:28 or 29 and an LC variable domain having the amino acid sequence shown in SEQ ID NO:30.
Dependencies are inferred from the claim text.