Loading patent…
AssigneesBeijing Gefucure Biotechnology Limited Company, Wuxi Kingenew Biotechnology Limited Company
InventorsBo Tang, Ran Zhang, Jianmin Zhao, Jianwu Wang, Yunping Dai
Estimating the term…
Provided is an afucosylated monoclonal antibody. The monoclonal antibody is a human IgG antibody and has an afucosylated sugar chain structure at a heavy-chain sugar chain binding site. Also provided are application of the monoclonal antibody in the preparation of antineoplastic drugs, and a composition containing the monoclonal antibody. Compared with a fucosylated monoclonal antibody, the provided afucosylated monoclonal antibody has higher biological activity in vitro and in vivo and can be used for developing more effective therapeutic monoclonal antibody drugs.
An afucosylated monoclonal antibody, wherein, the monoclonal antibody is a human IgG antibody, and the glycoform core structure of the monoclonal antibody is mainly afucosylated glycoform.
Dependencies are inferred from the claim text.