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US 2020/0270268 A1Published application
Crystalline forms of hydrochloride salts of thienopyrimidine compound
AssigneeHanmi Pharm. Co., Ltd.
InventorsJong Ouk BAEK, Ji Young JEON, Hee Sook OH, Hee Cheol KIM, Sun Young JANG, Tae Hee HA
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Abstract
The present invention relates to a crystalline form of a hydrochloride salt of N-(3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-yloxy)phenyl)acrylamide, and a pharmaceutical composition containing the same. The crystalline form of the hydrochloride salt of the compound can be easily used for preparing a pharmaceutical composition containing the same as an active ingredient.
Claims56
A hydrochloride salt of the compound of Formula 1:
A crystalline form of a hydrochloride salt of the compound of Formula 1
- prepared by a process comprising the steps of
- (a) adding an aqueous solution of an alcohol to the free base of the compound of Formula 1;
- (b) adding 1.5 to 3 eq. of HCl to the mixture obtained in step (a) (in relation to the free base);
- and
- (c) collecting the resulting precipitate.
2 more elements
Dependencies are inferred from the claim text.