Compounds, compositions and methods of use

A compound of Formula (I):

• or a pharmaceutically acceptable salt thereof, wherein:
• each of Ring A and Ring B is independently cycloalkyl, heterocyclyl, aryl, or heteroaryl;
• X is C(R′)(R″), O, or S(O)x;
• each of L1 and L2 is independently —C1-C6 heteroalkyl-, —NRA—, —C(O)NRA—, —NRAC(O)—, —C(O)NRA—C1-C6 alkyl-, —C1-C6 alkyl-C(O)NRA—, —NRAC(O)—C1-C6 alkyl-, —C1-C6 alkyl-NRAC(O)—, —C(O)NRA—C1-C6 heteroalkyl-, —C1-C6 heteroalkyl-C(O)NRA—, —NRAC(O)—C1-C6 heteroalkyl-, —C1-C6 heteroalkyl-NRAC(O)—, —C1-C6 heteroalkyl-C(O)—, or —C(O)—C1-C6 heteroalkyl-, each of which is optionally substituted with 1-5 R4;
• each of R1 and R3 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, halo, cyano, nitro, azido, cycloalkyl, heterocyclyl, aryl, heteroaryl, —ORB, —C(O)RD, —C(O)ORB, —NRARC, —NRAC(O)RD, —S(O)xRE, —OS(O)xRE, —C(O)NRAS(O)xRE, —NRAS(O)xRE, or —S(O)xNRA, each of which is optionally substituted with 1-5 R5;
• or
• each R2 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, halo, cyano, or nitro;
• each of R′ and R″ is independently H, C1-C6 alkyl, or C1-C6 heteroalkyl;
• each R4 is independently deuterium, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, halo, cyano, cycloalkyl, heterocyclyl, —ORB, —C(O)RD, —C(O)ORB, —C(O)NRARC, or —SRE, each of which is optionally substituted with 1-5 R6;
• or one R4, taken together with the atoms to which it is attached, forms a ring (e.g., a 5-7 membered ring) with Ring A, optionally substituted with 1-5 R5;
• or two R4, taken together with the atoms to which they are attached, form a ring (e.g., a 3-7 membered ring), optionally substituted with 1-5 R6;
• each R5 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, halo, cyano, or oxo;
• or two R5, taken together with the atoms to which they are attached, form a ring (e.g., a 3-7 membered ring), optionally substituted with 1-5 R6;
• each RA, RB, RC, RD, or RE is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C1-C6 haloalkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl, each of which is optionally substituted with 1-4 R6;
• or RA and RC, together with the atoms to which each is attached, form a heterocyclyl ring optionally substituted with 1-4 R8;
• each R6 is independently C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 heteroalkyl, C2-C6 heteroalkenyl, C2-C6 heteroalkynyl, C1-C6 haloalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, halo, cyano, or nitro;
• each of n, o, and p is independently 0, 1, 2, 3, 4, 5, or 6;
• and
• x is 0, 1, or 2;