Nucleic acids encoding antibodies specifically binding to masp-3
AssigneeOmeros Corporation
InventorsW. Jason Cummings, Gregory A. Demopulos, Thomas Dudler, Larry W. Tjoelker, Christi L. Wood, Munehisa Yabuki
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Abstract
The present invention relates to MASP-3 inhibitory antibodies and compositions comprising such antibodies for use in inhibiting the adverse effects of MASP-3 dependent complement activation.
Claims13
A cloning or expression vector comprising a nucleic acid encoding complementarity determining regions (CDRs) of heavy and light chain variable regions of an antibody, or antigen-binding fragment thereof, that binds to human MASP-3, wherein the heavy chain variable region comprises the amino acid sequence set forth as SEQ ID NO:254 or SEQ ID NO:255 and the light chain variable region comprises the amino acid sequence set forth as SEQ ID NO:45, SEQ ID NO:256 or SEQ ID NO:280.
A cell comprising:
- (a) a nucleic acid encoding complementarity determining regions (CDRs) of a heavy chain variable region of an antibody, or antigen-binding fragment thereof, that binds to human MASP-3, wherein the heavy chain variable region comprising the amino acid sequence set forth in SEQ ID NO:255;
- and
- (b) a nucleic acid encoding complementarity regions (CDRs) of a light chain variable region of an antibody, or antigen-binding fragment thereof, that binds to human MASP-3, wherein the light chain variable region comprises the amino acid sequence set forth in SEQ ID NO:280.
Dependencies are inferred from the claim text.