Rna-modulating agents
AssigneeUniversity of Massachusetts
InventorsPhillip D. Zamore, Jennifer Broderick
Life of this patent
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Abstract
The instant disclosure provides RNA-modulating agents that function to recruit one or more small regulatory RNA molecules (e.g., miRNA molecules, Y RNAs, and siRNAs) to a target mRNA thereby modulating (e.g., inhibiting) the translation of the target mRNA or destabilizing the mRNA. Also provided are miRNA inhibitors and diagnostic agents that have improved binding affinity for their target miRNAs. Methods for using the RNA-modulating agents, miRNA inhibitors and diagnostic agents are also provided.
Claims30
An RNA-modulating agent comprising an mRNA binding sequence that is complementary to a portion of a target mRNA sequence, linked to two or more miRNA binding sequences, wherein one or more of the miRNA binding sequences are complementary to at least positions 2 to 8 of an miRNA, but not complementary to positions 10 and 11 of the miRNA.
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An isolated miRNA binding sequence that is complementary to at least positions 2 to 8 of an miRNA, but not complementary to positions 10 and 11 of the miRNA.
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Dependencies are inferred from the claim text.