Compositions and Methods for Treating Heart Disease via Redirected T Cell Immunotherapies
AssigneeThe Trustees of the University of Pennsylvania
InventorsJonathan EPSTEIN, Haig AGHAJANIAN
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Abstract
The present invention includes compositions and methods for treating heart disease and/or heart failure. In one embodiment, the treatment includes administering to the subject a cell genetically modified to express a chimeric antigen receptor (CAR), comprising an antigen binding domain specific for fibroblast activation protein (FAP). In another embodiment, the treatment includes administering a cell genetically modified to express a T cell receptor (TCR) specific for an activated fibroblast.
Claims13
A method for treating heart disease and/or heart failure in a subject in need thereof, the method comprising administering to the subject a cell genetically modified to express a chimeric antigen receptor (CAR), wherein the CAR comprises an antigen binding domain specific for fibroblast activation protein (FAP).
A method for treating heart disease and/or heart failure in a subject in need thereof, the method comprising administering to the subject a cell genetically modified to express a T Cell Receptor (TCR) specific for an activated fibroblast.
Dependencies are inferred from the claim text.