Methods of modulating protein exocytosis and uses of same in therapy
AssigneeYeda Research and Development Co. Ltd.
InventorsYifat MERBL, Ron BENYAIR
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Abstract
A method of modulating protein exocytosis is provided. The method comprising contacting a cell with an agent that modulates the ubiquitin pathway in the Golgi, thereby modulating protein secretion.
Claims31
A method of treating a pathogenic condition associated with a secreted or membrane presented protein, the method comprising administering to a subject in need thereof an agent that modulates the GQC machinery, thereby treating the pathogenic condition associated with the aberrant protein exocytosis.
A method of diagnosing a medical condition, the method comprising analyzing activity or expression of the GQC machinery in a subject in need thereof, wherein an aberrant activity or expression of the GQC in the subject is indicative of a medical condition.
Dependencies are inferred from the claim text.