Compositions and methods for inhibiting blood cancer cell growth
AssigneesUniversity of New Brunswick, Universite de Moncton
InventorsAlli Murugesan, Anthony Reiman, Mohamed Touaibia
Life of this patent
Estimating the term…
Abstract
Methods, compositions and uses for inhibiting the growth in blood cancer cells with one or more of caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE), CAPE analogue MT30, and CAPE analogue GL8. The blood cancer cells can be myeloma, lymphoma and leukemia cells. The methods, compositions and uses can be in conjunction with the use of an IMiD to treat a patient. The compositions can include a pharmaceutically acceptable carrier, adjuvant or vehicle, a pharmaceutically acceptable salt or dietary supplement.
Claims48
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method for inhibiting the growth of blood cancer cells in a patient comprising:
- administering to a patient a therapeutically effective amount of a caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) analogue selected from the group consisting of MT30, and GL8, according to the formulae:
A composition for inhibiting the growth of blood cancer cells comprising:
- a therapeutically effective amount of a caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) analogue selected from the group consisting of MT30, and GL8, according to the formulae:
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
A method of decreasing a cereblon pathway protein in a patient comprising:
- administering to the patient a therapeutically effective amount of a caffeic acid (3,4-dihydroxycinnamic acid) phenethyl ester (CAPE) analogue selected from the group consisting of MT30, and GL8, according to the formulae:
The method of claim 39, wherein the cereblon pathway protein is selected from the group consisting of Ikaros and IRF4.
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
(canceled)
Dependencies are inferred from the claim text.