Sterile and sterilized package for administration of medicinal or nutritional substances

A package for administration of medicinal or nutritional substances, comprising an outer bag with a sterile or sterilized inner chamber and, within said chamber, a bottle of medicinal or nutritional substance with a neck and a pierceable cap set in an overturned position and a device for the withdrawal and/or reconstitution of the substance contained in the bottle which may be hooked to the neck of the bottle and comprises a needle for the perforation of the cap of the bottle which is axially movable with respect to the bottle, and an outflow tube extending out of the bag and equipped with an openable closure element, wherein said perforation needle is passed through longitudinally by a first channel connecting—after perforation of the cap and with the closure element set open—the inside of the bottle to said outflow tube, and a second channel with a side opening equipped with a hydrophobic filter configured to allow, after perforation of the cap, only air or other gaseous fluid to flow from inside the bottle into the inner chamber of the bag or vice versa.