Glypican-3-binding fibronectin based scaffold molecules

A nucleic acid encoding polypeptide comprising a tenth fibronectin type III (10Fn3) domain comprising BC, DE and FG loops, wherein the polypeptide binds specifically to human glypican-3 (GPC3), and wherein

• (a) the BC, DE and FG loops comprise SEQ ID NOs:
• 6, 7 and 8, respectively;
• (b) the BC, DE and FG loops comprise SEQ ID NOs:
• 19, 20 and 21, respectively;
• (c) the BC, DE and FG loops comprise SEQ ID NOs:
• 32, 33 and 34, respectively;
• (d) the BC, DE and FG loops comprise SEQ ID NOs:
• 45, 46 and 47, respectively;
• (e) the BC, DE and FG loops comprise SEQ ID NOs:
• 58, 59 and 60, respectively;
• (f) the BC, DE and FG loops comprise SEQ ID NOs:
• 71, 72 and 73, respectively;
• (g) the BC, DE and FG loops comprise SEQ ID NOs:
• 84, 85 and 86, respectively;
• (h) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 101, respectively;
• (i) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 129, respectively;
• (j) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 156, respectively;
• (k) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 183, respectively;
• (l) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 210, respectively;
• (m) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 237, respectively;
• (n) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 264, respectively;
• (o) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 291, respectively;
• or
• (p) the BC, DE and FG loops comprise SEQ ID NOs:
• 99, 100 and 318, respectively.