Dihydro-pyrrolo-pyridine derivatives

A compound of Formula (I):

• or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein:
• each R1, when present, is independently selected from the group consisting of halogen, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, optionally substituted (C3-C6)cycloalkyl, optionally substituted —O—(C3-C6)cycloalkyl, —N(R4)(R5), —N(R4)(C═(O)(R5), —C(═O)N(R4)(R5), —O—C(═O)—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR4;
• a is an integer selected from 0, 1, 2, and 3;
• each R2, when present, is independently selected from the group consisting of hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R4)(R5), —N(R4)(C═(O)(R5), —C(═O)N(R4)(R5), —O—C(═O)—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR4;
• b is an integer selected from 0, 1, 2, 3, and 4;
• R3, when present, is independently selected from the group consisting of halogen, cyano, hydroxy, oxo, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, optionally substituted (C3-C6)cycloalkyl, optionally substituted —O—(C3-C6)cycloalkyl, optionally substituted (5- to 6-membered)heteroaryl, —N(R4)(R5), —N(R4)(C═(O)(R5), —C(═O)N(R4)(R5), —O—C(═O)—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR, provided that when R3 is oxo, then s a single bond, or when c is 0 then R3 is absent and is a double bond;
• c is an integer selected from 0 and 1;
• L is selected from —(CH2)m—, and —O—, wherein m is an integer selected from 0, 1 and 2;
• A is absent or selected from the group consisting of (C3-C6)cycloalkyl and (4- to 10-membered)heterocycloalkyl, wherein said cycloalkyl and heterocycloalkyl are each optionally substituted with one to five substituents independently selected from the group consisting of halogen, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, —N(R4)(R5), —N(R4)(C═(O)(R5), —C(═O)N(R4)(R5), —O—C(═O)—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR4;
• E is selected from (C3-C12)cycloalkyl, (C6-C10)aryl, (5- to 6-membered)heterocycloalkyl, and (5- to 10-membered)heteroaryl, wherein said cycloalkyl, aryl, and heteroaryl are optionally substituted with one to five substituents independently selected from the group consisting of halogen, cyano, hydroxy, —SF5, nitro, optionally substituted (C1-C6)alkyl, optionally substituted (C2-C6)alkenyl, optionally substituted (C2-C6)alkynyl, optionally substituted (C1-C6)alkylthio, optionally substituted (C1-C6)alkoxy, optionally substituted (C3-C6)cycloalkyl, methyloxetanyl, —N(R4)(R5), —N(R4)(C═(O)R5), —C(═O)N(R4)(R5), —O—C(═O)—N(R4)(R5), —C(═O)—R4, and —C(═O)—OR4;
• and
• R4 and R5 at each occurrence are each independently selected from hydrogen and optionally substituted (C1-C6)alkyl;
• or R4 and R5 taken together with the nitrogen to which they are attached form an optionally substituted (4- to 6-membered)heterocycloalkyl.