Method for treating cancer based on metallofullerene monocrystalline nanoparticles that specifically disrupt tumor blood vessels

A method of treating a tumor, the method comprising:

• identifying a tumor-bearing organism in need of treatment,
• providing a tumor vascular disrupting agent comprising:
• an effective dose of metallofullerene monocrystalline nanoparticles, wherein the metallofullerene monocrystalline nanoparticles:
• are water-soluble;
• have negative charges on their surfaces;
• have a particle size that ranges from 50 to 250 nanometers;
• and
• have a rigidity that makes them get stuck when passing through a pore of a vessel wall of a tumor,
• administering the tumor vascular disrupting agent via an injection,
• providing a source of an outside radiation energy, wherein the source is matched with the metallofullerene monocrystalline nanoparticles, and wherein the metallofullerene monocrystalline nanoparticles are configured to absorb the outside radiation energy from the matched energy source, transform it into heat energy, accumulate the heat energy simultaneously, expand rapidly in volume due to phase transition, thereby causing a change in morphologies, structures, functions or combinations thereof of endothelium cells of tumor vessels, and
• irradiating a site of the tumor in the tumor-bearing organism with outside radiation energy from the matched source.