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US 2020/0206387 A1Published application
Cell Aggregate Including Retinal Tissue and Production Method Therefor
AssigneesRiken, Sumitomo Dainippon Pharma Co., Ltd.
InventorsMasayo Takahashi, Michiko Mandai, Suguru Yamasaki
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Abstract
A sphere-like cell aggregate according to one embodiment of the present invention comprises: a core part containing neural retina; and a covering part continuously or discontinuously covering at least a portion of a surface of the core part.
Claims21
A sphere-like cell aggregate comprising:
- a core part containing neural retina;
- and
- a covering part continuously or discontinuously covering at least a portion of a surface of the core part, wherein
- (1) in the neural retina, a neural retinal layer including at least a photoreceptor layer is formed, wherein the photoreceptor layer contains one or more types of cells selected from the group consisting of at least a photoreceptor cell, a photoreceptor progenitor cell, and a retinal progenitor cell, and the cells contained in the photoreceptor layer are continuously present in a tangential direction to the surface of the core part;
- (2) the covering part contains retinal pigment epithelial cells in contact with each other;
- (3) the cell aggregate is free of a crystalline lens, a vitreous, a cornea, and a blood vessel;
- and
- (4) the retinal pigment epithelial cells do not constitute an epithelial structure continued with the neural retinal layer.
5 more elements
Dependencies are inferred from the claim text.