In vivo immunoimaging of interferon-gamma
AssigneeWayne State University
InventorsNerissa Viola, Heather Gibson
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Abstract
Methods for in vivo immunoimaging including: (a) administering a labeled-antibody conjugate to a subject, wherein the labeled-antibody conjugate includes: an antibody that specifically recognizes and binds to IFN-γ, and a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer or fluorophore; and (b) detecting the presence of the radiolabeled-antibody conjugate in the subject in vivo by imaging. Embodiments of the present disclosure are directed to labeled-antibody conjugates and therapeutic radionuclide-antibody conjugates.
Claims24
A method for in vivo immunoimaging IFN-γ as a marker of active T cells in a subject, comprising:
- administering a labeled-antibody conjugate according to claim 19 to a subject, wherein the labeled-antibody conjugate comprises:
- an antibody that specifically binds to IFN-γ, and
- a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer or fluorophore;
- and
- detecting the presence of the labeled-antibody conjugate in the subject in vivo by imaging.
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A labeled-antibody conjugate comprising:
- an antibody that specifically binds to IFN-γ, and
- a detection label conjugated to the antibody, wherein the detection label is a radionuclide tracer.
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Dependencies are inferred from the claim text.