Suppression of allergic lung inflammation and hyperreactivity
AssigneeThe Regents of the University of California
InventorsReen Wu, Ching-Hsien Chen, Chen-Chen Lee
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Abstract
This disclosure relates to compositions of isolated polypeptides and methods of their use for the treatment and prevention of disease or disease symptoms associated with MARCKS phosphorylation and/or dissociation from the cell membrane, including but not limited to allergic inflammation, asthma, chronic bronchitis, COPD, infection, hyper-reactivity, cystic fibrosis, ulcerative colitis, Crohn's disease, irritable bowel syndrome, rosacea, eczema, psoriasis, acne, arthritis, rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus.
Claims21
1-12. (canceled)
A method for one or more of:
- preventing, reducing, delaying, inhibiting or suppressing disease or disease symptoms associated with MARCKS phosphorylation in a subject who does not suffer from cancer, comprising administering to the subject an effective amount of any one or more of an isolated polypeptide of any one of:
- (SEQ ID NO:
- 5)
- KKKRFSFKKSFK;
- (SEQ ID NO:
- 16)
- KKKRFAFKKAFK;
- (SEQ ID NO:
- 37)
- KKKKKRFSFKKSFKLSGFSFKKNKK;
- or
- (SEQ ID NO:
- 38)
- KKKKKRFAFKKAFKLAGFAFKKNKK.
A method for one or more of:
- preventing, reducing, delaying, inhibiting or suppressing disease or disease symptoms associated with MARCKS phosphorylation in a subject in need thereof, comprising administering to the subject an effective amount of any one or more of a polypeptide of the group of:
- (SEQ ID NO:
- 5)
- KKKRFSFKKSFK;
- (SEQ ID NO:
- 16)
- KKKRFAFKKAFK;
- (SEQ ID NO:
- 37)
- KKKKKRFSFKKSFKLSGFSFKKNKK;
- or
- (SEQ ID NO:
- 38)
- KKKKKRFAFKKAFKLAGFAFKKNKK,
- with the proviso that the subject does not suffer from cancer.
Dependencies are inferred from the claim text.