LACTATE DEHYDROGENASE A (LDHA) iRNA COMPOSITIONS AND METHODS OF USE THEREOF

A double stranded ribonucleic acid (dsRNA) agent for inhibiting expression of lactic acid dehydrogenase A (LDHA) in a cell, wherein the dsRNA agent comprises a sense strand and an antisense strand forming a double stranded region,

• wherein the antisense strand comprises at least 19 contiguous nucleotides differing by no more than 3 nucleotides from the nucleotide sequence 5′-AUCAGAUAAAAAGGACAACAUGC-3′ (SEQ ID NO:3408), wherein the antisense strand is 19-23 nucleotides in length,
• wherein all of the nucleotides of the sense strand are modified nucleotides,
• wherein the sense strand contains at least one motif of three 2′-F modifications on three consecutive nucleotides at or near the cleavage site,
• wherein all of the nucleotides of the antisense strand are modified nucleotides,
• wherein the antisense strand contains at least one motif of three 2′-O-methyl modifications on three consecutive nucleotides at or near the cleavage site, and
• wherein a ligand comprising one or more N-acetylgalactosamine (GalNAc) derivatives attached through a monovalent, bivalent, or trivalent branched linker is conjugated to at least one strand of the agent.