Methods for preventing or mitigating acute allergic responses using human milk oligosaccharides

A method for mitigating an immediate type allergic response in a subject in need thereof, the method comprising administering a nutritional composition to the subject, wherein the nutritional composition comprises a human milk oligosaccharide (HMO) component, the HMO component selected from the group consisting of fucosylated oligosaccharides, sialylated oligosaccharides, or a combination thereof.

The method of claim 18, wherein the fucosylated oligosaccharide is 2′-FL and the sialylated oligosaccharide is 6′-SL.

The method of claim 19, wherein a nutritional composition comprising both 2′-FL and 6′-SL is administered to the subject to mitigate an acute allergic response.

A method for reducing the severity of an allergic response in a subject in need thereof, the method comprising administering a nutritional composition to the subject, wherein the nutritional composition comprises a human milk oligosaccharide (HMO) component, the HMO component selected from the group consisting of 2′-FL, 6′-SL, or a combination thereof, wherein the human milk oligosaccharide is present in an amount effective to increase the antigen exposure levels required to trigger an allergic response.