Platelets loaded with anti-cancer agents
AssigneeCellphire, Inc.
InventorsKeith Andrew Moskowitz, Rafael Jorda, Ying Yi Zheng, Daniel Sheik
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Abstract
In some embodiments provided herein is a method of preparing cargo-loaded platelets, comprising: treating platelets with a cargo and with a loading buffer comprising a salt, a base, a loading agent, and optionally ethanol, to form the cargo-loaded platelets.
Claims51
A method of preparing drug-loaded platelets, comprising:
- treating platelets with a drug and with a loading buffer comprising a salt, a base, a loading agent, and optionally at least one organic solvent,
- to form the drug-loaded platelets.
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A method of preparing drug-loaded platelets comprising A) pooling platelets from a plurality of donors;
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- B) treating the platelets from step (A) with a drug and with a loading buffer comprising a salt, a base, a loading agent, and optionally at least one organic solvent, to form the drug-loaded platelets.
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The method of any one of the preceding claims, wherein the concentration of drug in the drug-loaded platelets is from about 1 nM to about 100 mM.
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The method of claim 469, wherein the PARP inhibitor is olaparib.
Dependencies are inferred from the claim text.