Anti-human cd69 antibody, and use thereof for medical purposes

An antibody comprising a light chain variable region and a heavy chain variable region,

• wherein the antibody binds to an epitope of the human CD69,
• wherein the light chain variable region comprises:
• CDR1 comprising the amino acid sequence of SEQ ID NO:
• 7;
• CDR2 comprising the amino acid sequence of SEQ ID NO:
• 8;
• and CDR3 comprising the amino acid sequence of SEQ ID NO:
• 9, 19 or 20, and
• wherein the heavy chain variable region comprises:
• CDR1 comprising the amino acid sequence of SEQ ID NO:
• 10;
• CDR2 comprising the amino acid sequence of SEQ ID NO:
• 11;
• and. CDR3 comprising the amino acid sequence of SEQ ID NO:
• 12
• wherein 1 to 3 amino acid residues are substituted in the amino acid sequences of SEQ ID NO:
• 9, 19 or 20, and
• wherein the amino acid sequence of CDR3 in the light chain variable region comprises:
• glutamine or glycine at the 1st position;
• serine at the 2nd position;
• tyrosine at the 3rd position;
• aspartic acid or threonine at the 4th position;
• and
• serine or threonine at the 5th position.

An antibody comprising a light chain variable region and a heavy chain variable region,

• wherein the antibody binds to an epitope of the human CD69,
• wherein the epitope consists of 12 or less amino acid residues and comprises the amino acid sequence of SEQ ID NO:
• 33,
• wherein the light chain variable region comprises:
• CDR1 comprising the amino acid sequence of SEQ ID NO:
• 7;
• CDR2 comprising the amino acid sequence of SEQ ID NO:
• 8;
• and CDR3 comprising the amino acid sequence of SEQ ID NO:
• 9, 19 or 20, and
• wherein the heavy chain variable region comprises:
• CDR1 comprising the amino acid sequence of SEQ ID NO:
• 10;
• CDR2 comprising the amino acid sequence of SEQ ID NO:
• 11;
• and CDR3 comprising the amino acid sequence of SEQ ID NO:
• 12
• wherein 1 to 3 amino acid residues are substituted, deleted, inserted, and/or added in the amino acid sequences of SEQ ID NO:
• 9, 19 or 20, and
• wherein the amino acid sequence of CDR3 in the light chain variable region comprises:
• glutamine or glycine at the 1st position;
• serine at the 2nd position;
• tyrosine at the 3rd position;
• aspartic acid or threonine at the 4th position;
• and
• serine or threonine at the 5th position.