Stem cell delivered oncolytic herpes simplex virus and methods for treating brain tumors
AssigneeThe General Hospital Corporation
InventorKhalid SHAH
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Abstract
Disclosed herein is an isolated stem cell or population thereof that comprises oncolytic herpes simplex virus (oHSV). Examples of possible stem cells include mesenchymal stem cells (MSC), neuronal stem cells and induced pluripotent stem cells. Various forms of the oHSV are disclosed. Also disclosed are methods of treating brain cancer in a subject by administering the stem cells containing oHSV to the subject to deliver the oHSV to brain cancer cells in the subject. The method is for the treatment of primary brain cancer and secondary metastatic brain cancer.
Claims13
A method of treating secondary multifocal brain tumors in a subject, comprising administering a pharmaceutical composition comprising an isolated stem cell or population thereof comprising infectious recombinant oncolytic herpes simplex virus (oHSV), wherein the isolated stem cell or population thereof is a non-cancer stem cell, and wherein the composition is formulated for systemic delivery via intracarotid injection to the subject to thereby contact cancer cells in the brain of the subject with oHSV.
Dependencies are inferred from the claim text.