Methods of treating neurodegenerative disease by inhibiting n-deacetylase n-sulfotransferase
AssigneeThe Penn State Research Foundation
InventorsScott Brian Selleck, Claire Reynolds-Peterson
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Abstract
A method of treating a subject suffering from a neurodegenerative disease characterized by insufficient autophagy is provided, the method comprising administering to the subject an effective amount of a composition that inhibits N-deacetylase N-sulfotransferase (NDST), Further provided is a method of identifying a modulator of autophagy.
Claims19
A method of treating a subject suffering from a neurodegenerative disease characterized by insufficient autophagy, the method comprising administering to the subject an effective amount of a composition that inhibits N-deacetylase N-sulfotransferase (NDST).
The method of claim 9, wherein detecting a change in enzymatic activity of the NDST polypeptide comprises detecting a change in deacetylation of GlcNAc and, detecting a change in formation of N-sulfo glucosamine (GlcNS).
A method of identifying a modulator of autophagy, the method comprising contacting an N-deacetylase N-sulfotransferase (NDST) polypeptide, a substrate for NDST, and a test substance under reaction conditions that promote specific interaction between the NDST polypeptide and the substrate for NDST, and detecting a change in enzymatic activity of the NDST polypeptide.
Dependencies are inferred from the claim text.