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US 2020/0164046 A1Published application
Inhibiting fak-akt interaction to inhibit metastasis
AssigneesBoard of Trustees of Michigan State University, University of North Dakota
InventorsMarc D. Basson, Leslie A. Kuhn, Sebastian Raschka
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Abstract
Methods and compositions are described herein that inhibit FAK/ATK interactions. Such methods and compositions are useful for inhibiting cell adhesion and cancer metastasis.
Claims16
An in vitro method comprising contacting one or more inhibitors of FAK/Akt1 in an assay comprising FAK and Akt1, and measuring adhesion between FAK and Akt1, wherein the inhibitor is:
- a. a peptide with a sequence comprising at least 95% sequence identity to SEQ ID NO:1, 2, 3, 4, 6, 7, 10, 11, 12-20, 21, or 22;
- b. an expression cassette comprising a promoter operably linked to a peptide with a sequence comprising at least 95% sequence identity to SEQ ID NO:1, 2, 3, 4, 6, 7, 10, 11, 12-20, 21, or 22;
- c. one or more compound with the following structure:
- or
- d. a combination thereof.
2 more elements
A method comprising administering one or more inhibitors of FAK/Akt1 to a mammal, wherein the inhibitor is:
- a. a peptide with a sequence comprising SEQ ID NO:1, 2, 3, 4, 6, 7, 10, 11, 12-20, 21, or 22;
- b. an expression cassette comprising a promoter operably linked to a peptide with a sequence comprising SEQ ID NO:1, 2, 3, 4, 6, 7, 10, 11, 12-20, 21, or 22;
- c. one or more compound with the following structure:
- or
- d. a combination thereof
- to thereby reduce at least one symptom of cancer in the mammal.
3 more elements
A compound of formula I:
- wherein:
- Ring A and Ring C independently are each an aryl ring;
- Ring B is a cycloalkyl ring;
- R1 is a lower alkyl or lower alkoxy;
- X is a C1 to C4 alkyl linker comprising a carbonyl, a carboxylate, an amide, a carboxylate(amino), or an aminocarboxylate group or a ═N—O—SO2— linker;
- and
- R2 and R3 are independently each a carboxylate, an amide, or a nitro group.
4 more elements
Dependencies are inferred from the claim text.