Acly inhibitors and uses thereof

A compound of formula I:

• or a pharmaceutically acceptable salt thereof, wherein:
• Ring A is a mono-, bi-, or tricyclic ring selected from
• Ring B is a ring selected from phenyl or 5-6 membered heteroaryl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• Ring C is a ring selected from phenyl or 5-6 membered heteroaryl having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• Ring D is a fused ring selected from benzo or 5-6 membered heteroaro-having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• X1 is a bivalent moiety selected from —CH2—, —CH(R1)—, —C(R1)2—, —C(O)—,
• or —O—;
• each R1 is independently independently hydrogen, —R3, halogen, —CN, —NO2, —OR, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, —OC(O)R, —OC(O)NR2, —OPh, —C(R)2Ph, —C(R)2OR, —C(R)2C(O)OR, —C(R)2C(O)NR2, —CH2C(R)2C(O)OR, —CH2C(R)2C(O)NR2, —CH2OPh, —N(R)C(O)OR, —N(R)C(O)R, —N(R)C(O)NR2, —N(R)S(O)2R, or —N(R)S(O)2NR2;
• or two instances of R1 are optionally taken together to form an oxo;
• or R1 at N forms an N-oxide;
• each R is independently hydrogen, or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or:
• two R groups on the same nitrogen are optionally taken together with their intervening atoms to form a 4-7 membered saturated, partially unsaturated, or heteroaryl ring having 0-3 heteroatoms, in addition to the nitrogen, independently selected from nitrogen, oxygen, and sulfur;
• each R2 is independently hydrogen, —R3, halogen, —CN, —NO2, —OR, —OC(R)2Ph, —SR, —NR2, —S(O)2R, —S(O)2NR2, —S(O)R, —C(O)R, —C(O)OR, —C(O)NR2, —C(O)N(R)OR, —OC(O)R, —OC(O)NR2, —C(R)2OR, —C(R)2C(O)OR, —C(R)2C(O)NR2, —CH2C(R)2C(O)OR, —CH2C(R)2C(O)NR2, —N(R)C(O)OR, —N(R)C(O)R, —N(R)C(O)NR2, —N(R)S(O)2R, or —N(R)S(O)2NR2;
• or two instances of R2 are optionally taken together to form an oxo;
• each R3 is independently an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-7 membered saturated or partially unsaturated carbocyclic ring, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
• each n is 0, 1, 2, 3, or 4;
• and
• each m is 0, 1, 2, 3, or 4.