Compound with kinase inhibitory activity and preparation method and use thereof

A compound represented by general formula (I) or (II), a pharmaceutically acceptable salt thereof, an isomer thereof, a solvate thereof, a polymorph thereof, a stable isotope derivative thereof or a prodrug thereof

• wherein,
• R1 and R2 are each independently selected from hydrogen, deuterium, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl;
• R3 and R4 are each independently selected from hydrogen, deuterium, halogen, hydroxyl, cyano, amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl;
• A is selected from CR8 or N, and R8 is selected from hydrogen, deuterium, halogen, hydroxyl, cyano, amino, alkenyl, alkynyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocycloalkyl;
• X1, X2, X3, and X4 are each independently selected from CR9 or N, and R9 is selected from hydrogen, deuterium, halogen, hydroxyl, cyano, amino, alkenyl, alkynyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• in R5 and R6,
• 1) R5≠R6, and R5 and R6 are each independently selected from hydrogen, deuterium, halogen, hydroxyl, mercapto, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted haloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylmercapto, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —OR10, —SR10, —NR10R10a, —CONR10R10a, —SO2NR10R10a, —C(O)tR11, —S(═O)tR11, —OC(═O)R11, —C≡CR11 or —CR11═CR11R11a, or R5 and R6 together with the carbon atom to which they are attached form C3-7 monocycloalkyl and bicycloalkyl, C5-12 spirobicyclic group or C5-12 bridged heterobicyclic group, or R5 and R6 together with the carbon atom to which they are attached form a cyclic moiety containing 1-3 heteroatoms, wherein the heteroatoms are selected from N, O, O, P or B;
• alternatively,
• 2) R5 and R6 are combined to form a substituted or unsubstituted exocyclic double bond
• W is selected from hydrogen, deuterium, halogen, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylmercapto, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —OR10, —SR10, —NR10R10a, —SO2NR10R10a, —C(O)tR11, —S(O)tR11, —OC(O)R11, —C≡CR11 or —CR11═—CR11R11a;
• Y1 is selected from N or CRa;
• Ya and Yb are each independently selected from —CR11R11a—, —N(R10), —C(═O)—, —S(═O)t or —O—;
• Y2 is selected from —CRaRb, —NRb, —C(═O), —S(═O)t, —S— or —O—;
• alternatively, Y1 and Ya, Y1 and Yb, Y2 and Ya, or Y2 and Yb form a C═C or C═N double bond;
• R7 is selected from hydrogen, deuterium, halogen, hydroxyl, cyano, oxo(=O), substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylmercapto, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —OR10, —SR10, —NR10R10a, —SO2NR10R10a, —C(O)tR11, —S(O)tR11, —OC(O)R11, —C≡CR11, —CR11═CR11R11a or —B(OR10)2, or a plurality of R7 together with the carbon atoms or heteroatoms to which they are attached form a cyclic moiety containing 0-3 heteroatoms, wherein the heteroatoms are selected from N, O, S, P or B;
• p is the number of substituents R3 and selected from 0, 1, 2 or 3;
• m and m are each independently selected from 0, 1, 2, 3 or 4;
• q is the number of substituents R7 and selected from 0, 1, 2, 3 or 4;
• t is 1 or 2;
• R10 is selected from hydrogen, deuterium, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylmercapto, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R10a is selected from hydrogen, deuterium, halogen, hydroxyl, amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylmercapto, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• alternatively, R10 and R10a together with the nitrogen atom to which they are attached form a cyclic moiety containing 1-3 heteroatoms, wherein the heteroatoms are selected from N, O, S, P or B;
• R11 and R11a are each independently selected from hydrogen, deuterium, halogen, hydroxyl, amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylmercapto, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• alternatively, R11 and R11a together with the carbon atom to which they are attached form a cyclic moiety containing 0-3 heteroatoms, wherein the heteroatoms are selected from N, O, S, P or B;
• Ra and Rb are each independently selected from hydrogen, deuterium, oxo(=O), halogen, hydroxyl, cyano, amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylmercapto, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —OR10, —SR10, —NR10R10a, —SO2NR10R10a, —C(O)tR11, —S(O)tR11, —OC(O)R11, —C≡CR11 or —CR11═CR11R11a;
• alternatively, Ra and Rb together with the carbon atom to which they are attached form monocycloalkyl and bicycloalkyl, C5-12 spirobicyclic group or C5-12 bridged heterobicyclic group, which containing 0-3 heteroatoms, wherein the heteroatoms are selected from N, O, S, P or B.