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US 2020/0149049 A1Published application
Methods and compositions relating to anti-calcification
AssigneeThe Brigham and Women's Hospital, Inc.
InventorsElena AIKAWA, Masaya IWASHITA, Masanori AIKAWA, Takehito OKUI
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Abstract
The technology described herein is directed to, e.g., methods of treating or preventing vascular calcification by modulating a novel calcification pathway which includes CROT, SLC20A1, PPAR?, HMOX1, STAT1, STAT3, and p38.
Claims14
A method of treating or preventing vascular calcification or treating or preventing calcification of a calcium deposit in a subject in need thereof, the method comprising administering to the subject
- an inhibitor of peroxisomonal carnitine octanoyltransferase (CROT);
- an inhibitor of SLC20A1;
- an agonist of PPARδ
- an agonist of HMOX1;
- an inhibitor of STAT1;
- an inhibitor of STAT3;
- and/or
- an inhibitor of p38.
5 more elements
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Dependencies are inferred from the claim text.