Ionic liquid based support for manufacture of peptides
AssigneeIndian Institute of Technology Delhi
InventorsSreedevi UPADHYAYULA, Tanmoy PATRA, Subhasis PAUL
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Abstract
The present invention relates to an ionic liquid based support of Formula-I: wherein: X− is a heteroatom containing cationic part; W is a halogen containing polymeric solid support; n is an integer in the range of 2 to 8; Y is a hydrophobic anion; R is selected from CO—Z or Z; Z is selected from the group consisting of —Cl, —Br, —OH, —O-Alkyl and combinations thereof. The present invention also relates to a process for preparation of said ionic liquid based support used for di, oligo or polypeptide manufacture.
Claims13
An ionic liquid based support of Formula-I:
- wherein:
- X+ is a heteroatom containing cationic part;
- W is a halogen containing polymeric solid support;
- n is an integer in the range of 2 to 8;
- Y− is a hydrophobic anion;
- R is selected from CO—Z or Z;
- Z is selected from the group consisting of —Cl, —Br, —OH, —O-Alkyl and combinations thereof.
A method for the preparation of an ionic liquid based support, comprising:
- i) attaching a heteroatom containing cationic part (X+) of an ionic liquid with a halogen containing polymeric solid support in an organic solvent at temperature in the range of 40° C. to 110° C. to obtain a solid product;
- ii) washing the solid product with another organic solvent to obtain a washed solid product;
- iii) subjecting the washed solid product to anion metathesis using a less hydrophilic or hydrophobic anionic source selected from the group consisting of methane sulfonate, triflate, hexafluorophosphate, trifluoromethanesulfonate, bistrifluoromethane sulfanimide, and tetrafluroborate or combinations thereof in a solvent under stirring conditions at a temperature ranging from 20° C. to 60° C. obtain an anion metathesis product;
- iv) drying the metathesis product at a temperature ranging from 60° C. to 120° C. under reduced pressure in between 60 mm Hg to 20 mm of Hg to obtain ionic liquid based support.
Dependencies are inferred from the claim text.