Using endoscopy as a channel to deliver cancer-or tissue-targeted theranostic agents
AssigneeAstrid Pharma Corp
InventorsR. Holland Cheng, Chun-Chieh Chen
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Abstract
The present disclosure provides a cancer-specific or tissue specific targeting theranostic capsule using hepatitis E viral nanoparticle (HEVNP) to enhance the accuracy of cancer diagnosis in endoscopic examinations, as well as treatment, for example hyperthermia treatment, after diagnosis. The present disclosure also provides a method of delivering a theranostic agent using the endoscopic apparatus, as well as a non-transitory computer readable medium storing a program that causes a computer to execute the method of the present invention.
Claims20
An endoscopic apparatus, comprising:
- a tubular body having a front end and an operating end, the tubular body comprising a fluid channel disposed inside the tubular body, the fluid channel having a fluid inlet at the operating end and a fluid outlet at the front end;
- a theranostic agent source coupled to the fluid inlet of the fluid channel and configured to supply a theranostic agent through the fluid channel;
- and
- a controller coupled to the operating end of the tubular body, wherein the controller is configured to control the operations of the endoscopic apparatus.
A method of delivering a theranostic agent using an endoscopic apparatus comprising a tubular body, an imaging system disposed inside the tubular body, an image displaying system coupled to the imaging system, an illumination system disposed inside the tubular body, a fluid channel disposed inside the tubular body, and a theranostic agent source coupled to the fluid channel, the method comprising:
- introducing the endoscopic apparatus into a body of a subject having a portion to be diagnosed and/or treated;
- illuminating an area around a front end of the endoscopic apparatus introduced into the body of the subject;
- delivering the theranostic agent from the theranostic agent source through the fluid channel to a portion to be diagnosed and/or treated;
- capturing, using the imaging system, images within the area around the front end of the endoscopic apparatus;
- displaying images captured by the imaging system with the image displaying system;
- and
- determining the condition of the theranostic agent supplied on the portion to be diagnosed and treated based on the images captured by the imaging system and displayed on the image displaying system.
Dependencies are inferred from the claim text.