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AssigneeUniversity-Industry Cooperation Group of Kyunghee University
InventorsDeok Chun YANG, Yeon Ju KIM, Mathiyalagan RAMYA
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The present invention relates to a conjugate of ginsenoside compound K and glycol chitosan, a method for preparing the conjugate, and a pharmaceutical composition for treating cancer including the conjugate in a pharmaceutically acceptable carrier. The conjugate of ginsenoside compound K and glycol chitosan of the present invention has cancer cell-specific anticancer activity because of increased water solubility relative to ginsenoside compound K, formation of nanosized self-aggregates in an aqueous solution, stability at neutral pH and release of the ginsenoside compound K at acidic pH due to pH sensitivity, thus having excellent effects as a composition for treating cancer.
1-16. (canceled)
A method for treating colorectal cancer, comprising administering a composition comprising conjugate of carboxylated ginsenoside compound K and glycol chitosan at a concentration of 10 μm/mL, wherein the conjugate comprises an amide bond and an ester linkage in binding sites, and wherein the conjugate releases the ginsenoside compound K at acidic pH.
Dependencies are inferred from the claim text.