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US 2020/0138955 A1Published application
Lipid compositions
AssigneeArbutus Biopharma Corporation
InventorsMuthiah Manoharan, Kallanthottathil G. Rajeev, Muthusamy Jayaraman, David Butler, Michael E. Jung
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Abstract
Disclosed herein are lipid compositions comprising a cationic lipid of formula (I), a neutral lipid, a sterol and a PEG or PEG-modified lipid, wherein formula (I) is Also disclosed are methods of producing the cationic lipid of formula (I).
Claims21
1-67. (canceled)
A lipid of formula (I):
- or a salt thereof, wherein,
- each Xa and Xb, for each occurrence, is independently C1-6 alkylene;
- n is 0, 1, 2, 3, 4, or 5;
- A for each occurrence is NR2 or a cyclic moiety optionally substituted with 1-3 R;
- B is NR or a cyclic moiety optionally substituted with 1-2 R;
- each R is independently H, alkyl,
- provided that at least one R is
- R1, for each occurrence, is independently H, R3,
- R2, for each occurrence, is independently, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl;
- R3, for each occurrence, is independently, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl;
- Y, for each occurrence, is independently O, NR4, or S;
- R4, for each occurrence is independently H alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, or heteroalkynyl.
9 more elements
Dependencies are inferred from the claim text.