Formulations for oral administration of active agents

A method of treating a condition treatable by oral administration of a therapeutically active agent in a subject in need thereof, the method comprising co-administering to the subject, by oral administration, an antacid composition comprising at least one antacid compound and/or at least one gastric acid secretion inhibitor, and a composition comprising said therapeutically active agent and SNAC (sodium 8-N-(2-hydroxybenzoyl)aminocaprylate), wherein said at least one antacid compound is selected from the group consisting of calcium citrate, calcium gluconate, sodium gluconate, sodium citrate, sodium hydroxide, potassium gluconate, potassium citrate, potassium hydroxide, magnesium gluconate, magnesium citrate, magnesium hydroxide, magnesium oxide, aluminum gluconate, aluminum citrate, and aluminum hydroxide, and said at least one antacid compound is administered in a total amount of at least 1 mg.

A pharmaceutical composition unit dosage form for oral administration of a therapeutically active agent, the unit dosage form comprising:

• a core comprising the therapeutically active agent and SNAC (sodium 8-N-(2-hydroxybenzoyl)aminocaprylate);
• and
• an external layer comprising at least one protective agent selected from the group consisting of an antacid compound in a total amount of at least 0.001 molar equivalent of base and a protease inhibitor.